Wednesday, March 20, 2019 | ePaper

Blood holds key to liver regeneration

Platelets are blood cells that help form clots and stop bleeding. When they receive information from fibrinogen, they go into action and accumulate in the remaining part of the liver to help restore it, increasing the chances of a fully functional liver and successful recovery

  • Print


Weekend Plus Desk :
he liver is the only organ in the body that can regenerate. A recent study shows that the blood-clotting protein fibrinogen may hold the key as to why some patients who undergo a liver resection, a surgery that removes a diseased portion of the organ, end up needing a transplant because the renewal process doesn't work.
“We discovered that fibrinogen accumulates within the remaining liver quickly after surgery and tells platelets to act as first responders, triggering the earliest phase of regeneration. But if fibrinogen or platelets are inhibited, then regeneration is delayed,” said James Luyendyk, lead author of the study published in the Journal Blood.
Platelets are blood cells that help form clots and stop bleeding. When they receive information from fibrinogen, they go into action and accumulate in the remaining part of the liver to help restore it, increasing the chances of a fully functional liver and successful recovery.
Using samples from patients undergoing liver resection and a comparable model in mice, Luyendyk and his team noticed that when fibrinogen was low, the number of platelets in the liver decreased.
“This shows that fibrinogen deposits are extremely important and directly impact regeneration in both mice and humans,” Luyendyk said.
According to Dafna Groeneveld, co-author of the study, their finding demonstrates that fibrinogen levels could be a predictive marker for doctors, too. “Measuring this protein in liver resection patients may help us determine in advance whether the organ will regenerate successfully or if it will become dysfunctional,” she said.
Researchers suggest that these findings could lead to new treatments that would help doctors correct low levels of the protein by using fibrinogen concentrates that can be administered during surgery.

More News For this Category

Bhutan in off-season

Bhutan in off-season

Akhil Sharma :here is only one traffic light in Bhutan. It is at the top of the main road in Thimphu, the country's capital. A policeman in a tight

From Aloo Parantha to Japanese Sticky Rice: Easy gluten-free recipes

From Aloo Parantha to Japanese Sticky Rice: Easy gluten-free recipes

Ingredients :Gluten-free chapati flour - 1 cup+1/3 cupWater to help you knead the doughSalt to tasteOnion - 1/2 super finely chopped.Green chillies - 2-3 finely (chopped)Green coriander - 10

Let others also live

Let others also live

Weekend Plus Desk :Onnojibon, a book based on articles, written by prominent Journalist Jamaluddin Jamal, was published recently by Nayaprobaho Prokashoni. In this book the author reflected the plights

Blood holds key to liver regeneration

Blood holds key to liver regeneration

Weekend Plus Desk :he liver is the only organ in the body that can regenerate. A recent study shows that the blood-clotting protein fibrinogen may hold the key as

Great leader

Great leader

    -Mohammad Mamun Mia Breaking the shackles of subjection We earned our emancipation The Bengali nation has not bowed down to the usurper Has no question to surrender Due

Sufi Literature Wakil Ahmed

ufi Literature, a distinctive stream of medieval Bangla literature, was inspired by Sufism. Sufi saints started coming to Bangladesh from Arabia and Iran in the mid-eleventh century. After Bakhtiyar

 Jules Verne: Life and writings

Jules Verne: Life and writings

Literature Desk :ules Verne (1828-1905) is frequently called the ‘father of science fiction.’ Among all writers, only Agatha Christie’s works have been translated more. Verne wrote numerous plays, essays,

Exposure to secondhand smoke can increase risk of kidney disease

Exposure to secondhand smoke can increase risk of kidney disease

Weekend Plus Desk :he perils of passive smoking need no retelling. However, according to a report quoted in The New York Times, being exposed to secondhand smoke can also

Ways to rebuild a relationship

Ways to rebuild a relationship

Weekend Plus Desk :ay be, we all know how a relationship crumbles when one partner breaks the trust of the other because trust is that solid rock upon which

Can you tell if your  child is lying?

Can you tell if your child is lying?

Weekend Plus Desk :hildren start lying as early as two years old and they’re really good at it, developmental researcher Kang Lee tells us in this Ted Talk. Having