Tuesday, November 20, 2018 | ePaper

BREAKING NEWS:

Stem cell therapy to treat heart-failure

  • Print


Life Desk :
Stem cells may potentially be used as a "one-and-done" approach to restore function in people with heart-failure, a study has found. Reported in the journal Nature Biotechnology, the study showed human stem cell treatment can possibly return the hearts' functioning to better than 90 per cent of normal in macaque monkeys with heart attacks. Heart-failure that causes nearly 10 million deaths worldwide, is a condition caused by lack of blood flow. The stem cells will help "form new muscle that will integrate into heart so it may pump vigorously again," said Charles "Chuck" Murry, Professor at the University of Washington.
"Our findings show that human embryonic stem cell-derived cardiomyocytes can re-muscularise infarcts in macaque monkey hearts and, in doing so, reduce scar size and restore a significant amount of heart function. This should give hope to people with heart disease," Murry said. For the study, the team induced experimental heart attacks in macaque monkeys.
Two weeks later, the researchers took heart cells that they had grown from embryonic human embryonic stem cells and injected them into and around the young scar tissue. Each animal received roughly 750 million of these human embryonic stem cell-derived cardiomyocytes. At four weeks after treatment, the ejection fraction in the treated animals rose to 49.7 per cent, about half-way back to normal, as compared to the untreated control animals, which remained unchanged at about 40 per cent. MRI scans showed that new heart muscle had grown within what had been scar tissue in the treated hearts, while no new muscle was seen in the untreated animals.
Moreover, the human heart cells had also formed new muscle tissue in the damaged region. The new muscle tissue had replaced 10 per cent to 29 per cent of the scar tissue, integrated with the surrounding healthy tissue and developed into mature heart cells, the researchers said. Murry said that the research aims to develop a treatment that could be given to people shortly after a heart attack to prevent heart failure.
Because heart cells are long-lived there should be no need for additional treatments, he said. The transplanted stem cells would also be genetically altered to reduce the risk of immune rejection, which often complicates organ transplantation. "What we hope to do is create a "one-and-done" treatment with frozen "off-the-shelf" cells that, like O-negative blood, can go into any recipient with only moderate immune suppression," Murry said.
-Internet

More News For this Category

BHOLA: Members of Coast Guard seized about 300 kgs jatka from Hilsa Ghat in Bhola  on Sunday.

BHOLA: Members of Coast Guard seized about 300 kgs jatka from Hilsa Ghat in Bhola on Sunday.

.

BETAGI (Barguna): Participants observing one minute silence marking the memories of Sidr at Betagi Upazila organised by Dhrubotara Youth Development Foundation on Thursday.

BETAGI (Barguna): Participants observing one minute silence marking the memories of Sidr at Betagi Upazila organised by Dhrubotara Youth Development Foundation on Thursday.

.

JALDHAKA(Nilphamari):  Upazila Chairman Alhaj Syed Ali joined BNP at a function recently. BNP Secretary General Mirza Fakhrul Islam Alamgir was present on the occasion.

JALDHAKA(Nilphamari): Upazila Chairman Alhaj Syed Ali joined BNP at a function recently. BNP Secretary General Mirza Fakhrul Islam Alamgir was present on the occasion.

.

BOGURA: A Fish Fair was held at Utholi Village in Shibganj Upazila in observance of the Nabanna Festival on Sunday.

BOGURA: A Fish Fair was held at Utholi Village in Shibganj Upazila in observance of the Nabanna Festival on Sunday.

.

News In Brief

World Antibiotic Awareness Week observed at RURU CorrespondentThe World Antibiotic Awareness Week was observed in Rajshahi University with the theme of "to take an unnecessary antibiotic is harm, without

Over Tk 15 cr collected  from Income Tax Fair in dists

Over Tk 15 cr collected from Income Tax Fair in dists

Barisal Correspondent : A total  of Tk 3.90 cores collected as taxes in first four days of the seven-day ' ninth Income-Tax Fair-2018' organised by National Board of Revenue (NBR).The

Unidentified man found dead in Narsingdi

UNB, Narsingdi :Police recovered the body of an unidentified young rickshaw-puller from Sebhasangha intersection in Sadar upazila on Saturday morning.Mizan, a sub-inspector (SI) of Sadar Police Station, said locals

Old woman killed in Chandpur road mishap

Chandpur  Correspondent :An old woman was killed while a small child among four others   sustained serious injuries as a truck loaded with shah brand cement and an auto rickshaw

'Wife' throws acid on husband in Rajshahi

RU Correspondent :Rajshahi, November 18: A husband became victim of acid attack by his wife over a trifling matter at Darikhorbona area in the city on Saturday night. Victim

Rajshahi PWD implements Tk1108.14 cr projects

BSS, Rajshahi :Public Works Department (PWD) has implemented 247 projects involving around Tk 1108.14 crore during the last 10 years in Rajshahi division benefiting its people in many ways.