Tuesday, March 19, 2019 | ePaper

Grapes to ward off depression

  • Print


Life Desk  :
Including grapes in your diet may have a positive impact on your mental health as researchers have found that certain grape-derived compounds might be developed as therapeutic agents for the treatment of depression. The results, published online in the journal Nature Communications, indicate that these natural compounds may reduce depression by targeting newly discovered underlying mechanisms of the disease.
"The discovery of these new, natural grape-derived polyphenol compounds targeting cellular and molecular pathways associated with inflammation may provide an effective way to treat a subset of people with depression and anxiety, a condition that affects so many people," said lead researcher Giulio Maria Pasinetti, Professor at Icahn School of Medicine at Mount Sinai in New York.
Depression is associated with a multitude of pathological processes, including inflammation of the peripheral immune system, a set of biological structures and processes in the lymph nodes and other tissues that protect against disease and abnormalities involving synapses, the structures that permit neurons to pass an electrical or chemical signal to other neurons.
However, currently available antidepressants are largely restricted to targeting the systems that regulate serotonin, dopamine, and other related neurotransmitters, and these treatments do not specifically address inflammation and synaptic maladaptations that are now known to be associated with major depressive disorder .
Previous research has found that grape-derived polyphenols have some efficacy in modulating aspects of depression, yet the mechanisms of action had largely remained unknown until now. The new study found that a bioactive dietary polyphenol preparation from grape was effective in promoting resilience against stress-induced depression in mice.
Specifically, the researchers found that two grape-derived compounds dihydrocaffeic acid (DHCA) and malvidin-3'-O-glucoside (Mal-gluc) can promote resilience in mouse models of depression by modulating inflammation and synaptic plasticity, respectively.
"Our research shows that combination treatment with the two compounds can promote resilience against stress-mediated depression-like phenotypes by modulating systemic inflammatory responses and brain synaptic plasticity in a mouse model of depression," said Jun Wang, Associate Professor at Icahn School of Medicine at Mount Sinai.
- IANS | New Delhi |

More News For this Category

Celebration of Women's Day at 'Amishee'

Celebration of Women's Day at 'Amishee'

Life Desk :'Amishee', celebrated Women's Day on 8th March, 2019 Friday. The Event took place at their outlet. The theme of IWD 2019 is 'Balance For Better'. A nod

When praise is a problem

When praise is a problem

Susan Krauss Whitbourne, Ph.D :How do you react when you've received a compliment? Perhaps you worked particularly hard to prepare a bowl of cole slaw for a potluck dinner

Importance of spiritual health

Importance of spiritual health

Dr. Mohammad Fazlul Karim :The issue of spiritual health has become an important aspect of human life, because it provides answers to many questions related to health and happiness. 

Mental disorders account for 13pc global burden of disease

Mental disorders account for 13pc global burden of disease

Life Report :Mental health constitutes a major public health challenge undermining the social and economic development throughout much of the developing world like Bangladesh, opined Prof Dr Md Harunur

Self-control may determine future earning

Life Desk :If you have self-control over the desire to get instant benefits, then you are more likely to earn higher income later, finds a study. In the study,

Spot toxic 'friends' in facebook

Wendy L. Patrick, PhD :We make friends quickly on social media; which is ironic, given the absence of the visual, verbal, and behavioral cues that we use every day

Can hunger make us more forgiving?

Can hunger make us more forgiving?

Rob Henderson :Many of us notice that we act differently when we're hungry. You might get more easily irritated or find it more challenging to focus. A new study

Parenting an adult addict can be a battle of wills

Parenting an adult addict can be a battle of wills

Suzanne Degges-White Ph.D. The strength of an addiction's hold on your child is a predictor of the magnitude of the fight you will face. When you first realize that

The big, the beautiful, and the healthy?

The big, the beautiful, and the healthy?

Cosmopolitan UK recently announced that Tess Holliday would be gracing the cover of their October 2018 issue. This announcement was met with controversy. Why? Well, Holliday is a plus-sized model.

Unlock your linguistic creativity

Unlock your linguistic creativity

Moses Ma :A sign of deep creativity is the ability to create new words on the fly. Consider William Shakespeare… he invented over 2000 words! He made up words